Restylane


Restylane is a FDA-approved dermal filler made of a biodegradable, non-animal stabilized hyaluronic acid (NASHA). Hyaluronic acid is a natural substance found in all living organisms and provides volume and fullness to the skin. Restylane is a gel of hyaluronic acid generated by Streptococcus species of bacteria. It is produced biotechnologically by natural fermentation in a sterile laboratory environment.

Restylane is indicated for mid-to-deep dermal implantation for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Restylane is also indicated for submucosal implantation for lip augmentation in patients over the age of 21. Restylane is formulated as a clear gel and uses a dual mechanism of action to correct moderate to severe wrinkles and folds. Upon being injected beneath the skin's surface, Restylane gel integrates into dermal tissue then attracts and binds to water molecules to help maintain volume. Restylane is gradually degraded by the body's own mechanism and disappears without any residue. Results can be seen immediately following Restylane treatment and for up to six months. Some patients may achieve results that last longer than six months, depending upon injection site.

Restylane is contraindicated: in patients with severe allergies, including allergies to gram positive bacterial proteins, in patients with bleeding disorders, for implantation in anatomical spaces other than the dermis or submucosal implantation for lip augmentation.

Adverse event summary from studies conducted for submucosal implantation for lip augmentation are Redness, Swelling, Pain/Soreness, Tenderness, Bruising, Itching, Headache, Skin Exfoliation.